Lipases and Phospholipases in Drug Development: From Biochemistry to
Molecular Pharmacology

By Günter Müller, Stefan Petry

Product Description:





Lipases and Phospholipases are key control elements in mammalian
metabolism. They share many common features that set them apart from
other metabolic enzyme classes, most importantly their association with
biological membranes. Their potential as drug targets for the treatment
of metabolic diseases is widely recognized, and the first lipase
inhibitor drugs have been successfully introduced.

The authors examine fundamental aspects of
lipase function in vitro and in vivo, explaining how this knowledge may
be used to develop lipase assays. They also treat the physiological
roles of lipases in normal and disordered metabolism, as well as
strategies to target lipases for the treatment of diabetes, obesity and
related disorders. Additional topics include the application of
phospholipases for liposome-based drug delivery and their use as
diagnostic tools.







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