Cyclic Nucleotide Phosphodiesterases in Health and Disease

By Joseph A. Beavo, Sharron H. Francis, Miles D. Houslay



Publisher: CRC

Number Of Pages: 728

Publication Date: 2006-12-05

ISBN-10 / ASIN: 0849396689

ISBN-13 / EAN: 9780849396687

Binding: Hardcover





Since the last major compendium dedicated to cyclic nucleotide
phosphodiesterases (PDEs) was published over 15 years ago, an enormous
amount of progress has occurred in the field. There is great need for a
centralized source for key information in this burgeoning and
therapeutically important area of medical research.

Cyclic Nucleotide Phosphodiesterases in Health and Disease provides an
integrated volume covering PDE biology from genes to organisms. It
examines phosphodiesterases as pharmacological targets as well as the
development of specific PDE inhibitors as therapeutic agents. With
contributions from pioneers in the field, individual chapters describe
one of the 11 known mammalian PDE families including the molecular
characteristics, structure, function, and traits unique to each.
Characteristics of PDEs from lower organisms are also the subject of
other chapters since they provide key insights into PDE functions and
are also pharmacological targets for treatment of a variety of diseases
in humans and domestic animals. Chapters on the current biomedical and
therapeutic research on PDEs include studies on gene-targeted knockout
strategies and compartmentation in cyclic nucleotide signaling. By
unraveling the unique cellular roles for different PDEs, scientists are
beginning to open the door to the therapeutic use of PDE inhibitors for
the treatment of a number of pathological conditions including asthma
and inflammation, pulmonary hypertension, erectile dysfunction, and
stroke.

By collating current information into a coherent and coordinated
perspective, Cyclic Nucleotide Phosphodiesterases in Health and Disease
provides an invaluable reference for industry and clinical scientists
and points toward future directions of research and therapeutic
advancements in developing selective inhibitors for these various
enzymes.



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