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| موضوع: طرق لتسهيل حفظ الفارما 24/03/10, 10:36 am | |
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Toxicology & Pharmacology.. الســــموم & الأدوية
Factors affecting the action of poisons DRS درس Dose Route of administration State
Drugs cause tachycardia CASH كاش Cocaine Atropine Amphetamine Salicylate Hashish
Drugs cause Bradycardia SODA صودا Sedative & hypnotics Opiate Digitalis Anticholinestrase
Poisons cause hypertension MCAN مكان Morphine withdrawal Cocaine Amphetamine Nicotine
Poisons cause Pupillary dilatation 2A , 2C , 2M Atropine Amphetamine
Cocaine CO
Menthol Morphine withdrawal
Poisons cause optic neuritis NML نمل Naphthalene Methanol Lead
Poisons decrease salivation MAN Morphine Atropine Nutmeg
Hepatotoxic drugs HEPATIC Hemolytic poisons Ethanol Paracetamol Aflatoxin Toxaphene Iron Chlorpromazine
Nephrotoxic drugs NEPHRO NSAIDS Ergot alkaloids Pre renal failure Heavy ****ls Rhabdomylosis causing drugs Oxalic acid
Drugs causing ****bolic acidosis TSLIM تســليم TCA Salicylate Lethium Iron Methanol
Poisons acting on Cerebral Cortex in ttt of convulsion 2A , 2C Atropine Amphetamine
Cocaine Caffine
First-aid Treatment of poisoning A B C D Airway >> Suction of secretion Breathing >> Oxygen via endotracheal tube Circulation >> I.V. injections Disability >> Convulsions & Coma
Symptomatic ttt of poisoning coma A B C D E F Antibiotics … to avoid infection
Bowel care … by enema Bladder care … by catheterization Buccal care … by frequent washing Blanket … to warm the patient Bed sores … change the position of the patient
Continuous monitoring of pulse , B.P. , temp and reflexes Dehydration … ttt by I.V. fluids Electrolytes
Fluid balance Feeding … by ryle tube & I.V. fluids
Naloxone … 4 respiratory depression >> 2mg i.v
Succinylcholine: action, use Succinylcholine gets Stuck to Ach receptor, then Sucks ions in through open pore You Suck stuff in through a mouth-tube, and drug is used for intubation
Cholinergics (eg organophosphates): effects If you know these, you will be LESS DUMB Lacrimation Excitation of nicotinic synapses Salivation Sweating Diarrhea Urination Micturition Bronchoconstriction
[size=16]Steroids: side effects BECLOMETHASONE Buffalo hump Easy bruising Cataracts Larger appetite Obesity Moonface Euphoria Thin arms & legs Hypertension/ Hyperglycaemia Avascular necrosis of femoral head Skin thinning Osteoporosis Negative nitrogen balance Emotional liability
Methyldopa: side effects METHYLDOPA Mental retardation Electrolyte imbalance Tolerance Headache/ Hepatotoxicity psYcological upset Lactation in female Dry mouth Oedema Parkinsonism Anaemia
Sodium valproate: side effects VALPROATE Vomiting Alopecia Liver toxicity Pancreatitis/ Pancytopenia Retention of fats Oedema Appetite increase Tremor Enzyme inducer
Captopril (an ACE inhibitor): side effects CAPTOPRIL Cough Angioedema/ Agranulocystosis Proteinuria/ Potassium excess Taste changes Orthostatic hypotension Pregnancy contraindication/ Pancreatitis/ Pressure drop Renal failure (and renal artery stenosis contraindication)/ Rash Indomethacin inhibition Leukopenia/ Liver toxicity
Lithium: side effects LITH Leukocytosis Insipidus [diabetes insipidus, tied to polyuria] Tremor/ Teratogenesis Hypothyroidism
Opioids: effects BAD AMERICANS Bradycardia & hypotension Anorexia Diminished pupilary size Analgesics Miosis Euphoria Respiratory depression Increased smooth muscle activity Constipation Ameliorate cough reflex Nausea and vomiting Sedations
Ca++ channel blockers: uses CA++ MASH
Cerebral vasospasm/ CHF Angina Migranes Atrial flutter, fibrillation Supraventricular tachycardia Hypertension
Alternatively > CHASM Cererbral vasospasm / CHF Hypertension Angina Suprventricular tachyarrhythmia Migranes
HMG-CoA reductase inhibitors (statins): side effects, contraindications, interactions HMG-CoA • Side effects Hepatotoxicity Myositis • Contraindications Girl during pregnancy/ Growing children • Interactions Coumarin/ Cyclosporine
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